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. 2019 Jun 13;12:35. doi: 10.1186/s13072-019-0283-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — SSTR5-AS1 upregulates SSTR5 expression through interacting with MLL3. a Overexpression of SSTR5-AS1 increased mRNA expression level of SSTR5 in AMC-HN-8 cells. *P < 0.05. b Overexpression of SSTR5-AS1 increased protein expression level of SSTR5 in AMC-HN-8 cells. c RIP assay showed the binding of SSTR5-AS1 to MLL3 in SSTR5-AS1-transfected AMC-HN-8 cells. *P < 0.05. d Co-expression of SSTR5-AS1 and MLL3 had a synergistic promoting effect on the mRNA up regulation of SSTR5. *P < 0.05. e Co-expression of SSTR5-AS1 and MLL3 had a synergistic promoting effect on the protein overexpression of SSTR5. f ChIP assay revealed that overexpression of SSTR5-AS1 increased the enrichment of MLL3 and the level of H3K4me3 at the promoter region of SSTR5. *Compared with empty vector, P < 0.05. g The expression level of SSTR5 was positively correlated with MLL3 in HNSC in LinkedOmics dataset