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. 2019 Jun 6;10:351. doi: 10.3389/fendo.2019.00351

Figure 3.

Figure 3

Blockade of VP receptors decreased bacillary loads at lung. (A) Comparison of bacillary loads at lung homogenates of control mice treated with vehicle (black-filled bars) and treated with CVP (lined bars) from day 60. (B) Effect on bacillary loads of vehicle treated (black-filled bars), CVP (lined bars), the three antibiotics (AB, Rifampicin, Isoniazide, and Ethambutol, gray filled bars) and antibiotics plus CVP (AB + CVP, white bars), during late infection, from day 60. (C) Pneumonic areas of the infected lungs of mice treated with the different experimental conditions. (D–G) Representative micrographs of automatized reconstruction of infected lungs from vehicle, CVP, AB, and CVP plus AB, respectively. Days 75, 90, and 120 of infection correspond to 15, 30, and 60 days of treatment, respectively. Data are expressed as means ± SD of three different animals at each point. Asterisk represent statistical significance (*P < 0.05, two-way ANOVA).