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. 2018 Sep 21;286(9):1624–1637. doi: 10.1111/febs.14654

Figure 3.

Figure 3

Modulation of interferon regulatory factor 5 (IRF5) via post‐translational modification. (A) Schematics of putative IRF5 phosphorylation and ubiquitination sites (human isoform v3/v4) and their positions with respect to functional domains. Suggested targets and functions of mapped sites are also shown (B) Inhibition of IRF5 phosphorylation through the use of kinase inhibitors. Kinases reported to phosphorylate IRF5 include IRAK4, TAK1, RIP2, IKKα, IKKβ, IKKε and TBK1.