Table 1.

Summary of strategies to study and modulate interferon regulatory factor 5 (IRF5) function

Mode of action	Class of drug	Advantages	Disadvantages
Inhibition of IRF5 gene expression	Small interfering RNA	Selectivity	Off‐target effects Delivery
Inhibition of IRF5 gene expression	CRISPR/Cas9	Easy design High efficiency	Off‐target effects
IRF5 overexpression	Adenoviral vector	High transduction efficiency High levels of transgene expression	Transient transfer and expression
Disruption of IRF5–protein interactions	Peptide inhibitors	Selectivity	Low proteolytic stability Low conformational stability
Disruption of IRF5–DNA interactions	Decoy oligonucleotides	Selectivity	Delivery
Inhibition of IRF5 kinases	Kinase inhibitors	Targetable by small molecule inhibitors	May interfere with other signalling pathways