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Subgroup analyses of treatment effect in predefined subgroups for the composite endpoint (A), recurrent AIS (B), ICH (C), and mortality (D). AIS = acute ischemic stroke; DOAC = direct oral anticoagulant; HR = hazard ratio; ICH = intracranial hemorrhage; NIHSS = National Institute of Health Stroke Severity Scale; VKA = vitamin K antagonist. [Color figure can be viewed at www.annalsofneurology.org]
