Table 2.

Biocatalytic transformation of substrate 2 d by 2‐ODD‐PH.

Entry	Scale	Conv.	11 d [%]		(+)‐2 d [%]
		[%][a]	Yield[b]	ee [d]	Yield[b]	ee [c]
1	1 mg	50	–[e]	99	–[e]	99
2	100 mg	43	38	95	50	72
3	2.0 g	41	39	95 (>99[f])	45	66

Reaction conditions: CFE (44 v %), 20 mm substrate, 2‐oxoglutarate (1.75 equiv), sodium ascorbate (3 equiv), 23 % DMSO as cosolvent, 18 h; the absolute configurations were determined by comparison to literature values.24 [a] The conversion was determined from calibrated HPLC‐UV spectra. [b] Yields of isolated, chromatographically pure, and fully characterized products are reported. [c] The ee values were determined by HPLC‐UV analysis on a chiral stationary phase (for details see the Supporting Information). [d] The ee value was determined from the conversion and the ee of the remaining substrate.25 [e] Yield of isolated product not determined. [f] The ee was determined by HPLC‐UV analysis of the follow‐up product 1 (see Scheme 2).