Table 2. Clinical and Imaging Outcomes.
| Outcome | Median (IQR) | Odds Ratio or Relative Risk (95% CI) Within Direct and Transfer Groups | P Value | ||||
|---|---|---|---|---|---|---|---|
| Direct (n = 61) | Transfer (n = 121) | ||||||
| Endovascular Therapy (n = 34) | Medical Therapy (n = 27) | Endovascular Therapy (n = 58) | Medical Therapy (n = 63) | Within Direct and Transfer Groups | For Difference of Treatment Effect in Direct vs Transfer | ||
| Primary efficacy outcome: score on (mRS) at 90 d | 3 (1-4) | 4 (3-5) | 3 (2-5) | 4 (3-6) | 2.9 (1.2-7.2) vs 2.6 (1.3-4.8) | .01 vs .009 | .80 |
| Secondary efficacy outcome: functional independence at 90 d, No. (%) | 15 (44) | 6 (22) | 26 (45) | 9 (14) | 2.0 (0.9-4.4) vs 3.1 (1.6-6.1) | .07 vs <.001 | .44 |
| 24-h NIHSS | 7.5 (5-15) | 15 (9-20) | 9 (5-20)d | 17 (12-21) | .01 vs .003 | .33 and .35 | |
| Discharge NIHSS | 4 (2-9) | 15 (4-20) | 5 (3-12) | 15 (8-21) | .005 vs <.001 | .28 and .50 | |
| Discharge mRS | 4 (2-4) | 5 (4-5) | 4 (2-5) | 4 (4-5) | .009 vs .007 | .74 and .88 | |
| Safety outcomes, No. (%) | |||||||
| Death at 90 d | 2 (6) | 6 (22) | 11 (19) | 17 (27) | 0.26 (0.02-1.16) vs 0.70 (0.36-1.37) | .12 vs .30 | .39 |
| Symptomatic intracranial hemorrhage | 1 (3) | 0 (0) | 5 (9) | 4 (6) | 2.4 (0.1-56.7) vs 1.36 (0.34-5.95) | >.99 vs .74 | >.99 |
| Early neurologic deterioration | 3 (9) | 3 (11) | 5 (9) | 9 (14) | 0.79 (0.14-4.59) vs 0.60 (0.21-1.70) | >.99 vs .33 | >.99 |
| Parenchymal hematoma type 2 | 3 (9) | 0 (0) | 5 (9) | 3 (5) | 5.6 (0.30-104.0) vs 1.8 (0.40-15.8) | .25 vs .48 | .53 |
| Imaging outcomes | |||||||
| Infarct volume at 24 h, mL | 38.0 (12.9-80.0) | 64.3 (14.8-159.4) | 32.2 (22.8-87.2) | 39.0 (28.1-89.0) | NA | .28 vs .33 | .76 and .63 |
| Infarct growth at 24 h, mL | 23.6 (5.8-55.3) | 41.9 (14.8-125.5) | 23.2 (11.6-76.8) | 30.1 (19.6-58.7) | NA | .12 vs .30 | .61 and .33 |
| Reperfusion >90% at 24 h, No. (%) | 22 (76) | 2 (9) | 37 (80) | 10 (22) | 8.3 (2.5-96.4) vs 3.7 (2.1-6.5) | <.001 vs <.001 | .65 |
| Complete recanalization at 24 h, No. (%) | 23 (74) | 2 (10) | 42 (81)d | 12 (21) | 7.4 (2.3-81.9) vs 3.8 (2.3-6.5) | <.001 vs <.001 | >.99 |
| TICI score of 2b or 3. No. (%) | 26 (76) | NA | 44 (76) | NA | NA | NA | .95 |
| Length of stay | |||||||
| Enrolling hospital only | 6.4 (4.4-10.5) | 9.3 (8.2-13.6) | 6.6 (3.2-8.9) | 8.7 (5.9-14.5) | NA | .03 vs .003 | .28 and .32 |
| Combined transfer and enrolling hospitals | NA | NA | 6.8 (3.3-8.9) | 9.1 (6.0-15.1) | NA | .03 vs .002 | .36 and .48 |
Abbreviations: IQR, interquartile range; mRS, Modified Rankin Scale score; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale score; TICI, modified thrombolysis in cerebral infarction.