. 2019 Jun 10;76(9):1099–1108. doi: 10.1001/jamaneurol.2019.1456

Table 2. Study-Wide Significant Gene-Based Test Results .

APOE ε4 Group	Chr	Start	End	Gene	SNV Influence	Model^a	No. Variants	cMAC	Sentinel Variant	No.	P Value
With ε4	11	124,134,751	124,135,752	OR8G5	High + moderate	2	3	267	rs200328143	3082	4.67 × 10⁻⁷
	14	106,518,415	106,518,824	IGHV3-7	All	2	4	11	rs188349361	2870	9.75 × 10⁻¹⁶
	20	19,261,606	19,261,724	SLC24A3	All	2	2	68	rs3790174	3082	2.67 × 10⁻¹²
Without ε4	6	41,126,505	41,130,815	TREM2	High + moderate	1	14	310	rs75932628	6656	2.75 × 10⁻⁸

Abbreviations: Chr, chromosome; cMAC, cumulative minor allele count; SNV, single-nucleotide variant.

^{^a}

Model 1: adjusted only for principal components; model 2, adjusted for age, sex, and principal components.