Table 1. Baseline Characteristics of Patients With Lacunar Infarcts.
| Variable | Patients, No. (%) | P Value | |
|---|---|---|---|
| Alteplase (n = 55) | Placebo (n = 53) | ||
| Age, mean (SD), y | 63 (10) | 62 (13) | >.99 |
| Male | 39 (71) | 35 (66) | .68 |
| Reason for unknown time of symptom onset | |||
| Night sleep | 51 (93) | 49 (93) | .57 |
| Day sleep | 3 (6) | 3 (6) | |
| Aphasia, confusion, or other | 1 (2) | 1 (2) | |
| Time between last-seen-well point and symptom recognition, median (IQR), min | 380 (270-480) | 360 (240-505) | .98 |
| Medical history or risk factors | |||
| Arterial hypertension | 27 (49) | 26 (49) | >.99 |
| Diabetes mellitus | 12 (22) | 6 (11) | .16 |
| Hypercholesterolemia | 18 (33) | 19 (36) | .92 |
| Atrial fibrillation | 1 (2) | 1 (2) | >.99 |
| History of ischemic stroke | 6 (11) | 5 (9) | >.99 |
| National Institute of Health Stroke Scale score, median (IQR) | 5 (4-7) | 4 (3-5) | .09 |
| Diffusion-weighted imaging lesion volume at baseline, median (IQR), mL | 0.8 (0.2-1.2) | 0.7 (0.2-1.1) | .45 |
| Vessel occlusion on time-of-flight magnetic resonance angiography | |||
| Intracranial internal carotid artery occlusion | 0 | 0 | NA |
| Middle cerebral artery occlusion | 0 | 0 | NA |
| Middle cerebral artery branch occlusion | 0 | 0 | NA |
| Othera | 2 (4) | 1 (2) | >.99 |
| Time from symptom recognition to magnetic resonance imaging, median (IQR), min | 165 (127-218) | 174 (138-210) | .80 |
| Time from symptom recognition to treatment initiation, median (IQR), min | 188 (158-250) | 210 (167-245) | .68 |
| Time between last-seen-well point and treatment initiation, median (IQR), min | 598 (434-695) | 590 (471-724) | .83 |
Abbreviations: IQR, interquartile range; NA, not applicable.
a
For example, anterior or posterior cerebral artery occlusion or vertebral or basilar artery occlusion.