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. 2019 Jun 10;179(8):1113–1121. doi: 10.1001/jamainternmed.2019.1201

Table 2. Primary Outcomes: Intervention vs Control Group.

Characteristic Intervention Control Intervention Effect (Adjusted)
Value, Mean (SD) Δ (95% CI)a P Valuea Value, Mean (SD) Δ (95% CI)a P Valuea DiD
(95% CI)
P Value
Asthma Control Test score
Baseline 14.8 (3.9) 14.3 (4.0)
3 mo 16.2 (4.4) 1.4 (0.8 to 2.0) <.001 14.6 (4.8) 0.4 (−0.5 to 1.2) .58 1.2 (0.2 to 2.2) .02
6 mo 16.2 (4.4) 1.4 (0.8 to 2.1) <.001 14.6 (4.9) 0.4 (−0.5 to 1.2) .37 1.0 (0.0 to 2.1) .049
12 mo 17.1 (4.7) 2.2 (1.5 to 2.9) <.001 16.1 (4.3) 1.5 (0.5 to 2.6) <.001 0.6 (−0.5 to 1.8) .28
Overall effectb χ24 = 13.4 .01
Mini Asthma Quality of Life score
Baseline 4.3 (1.2) 4.3 (1.1)
3 mo 4.7 (1.2) 0.4 (0.2 to 0.5) <.001 4.3 (1.3) 0.0 (−0.2 to 0.2) .91 0.4 (0.1 to 0.6) .007
6 mo 4.7 (1.3) 0.3 (0.1 to 0.5) <.001 4.3 (1.3) −0.1 (−0.3 to 0.2) .62 0.4 (0.1 to 0.7) .02
12 mo 4.8 (1.3) 0.5 (0.3 to 0.7) <.001 4.6 (1.3) 0.3 (0.0 to 0.5) .03 0.2 (−0.1 to 0.5) .20
Overall effectb χ24 = 10.5 .03
Medication Adherence Rating scale score
Baseline 3.6 (0.7) 3.8 (0.7)
3 mo 3.9 (0.6) 0.3 (0.2 to 0.4) <.001 3.8 (0.7) 0.1 (0.0 to 0.3) .50 0.2 (0.1 to 0.4) .01
6 mo 3.9 (0.7) 0.3 (0.2 to 0.4) <.001 3.8 (0.8) 0.0 (−0.1 to 0.2) .69 0.2 (0.0 to 0.4) .02
12 mo 3.9 (0.7) 0.3 (0.1 to 0.4) <.001 3.8 (0.7) 0.1 (−0.1 to 0.2) .70 0.3 (0.1 to 0.5) .01
Overall effectb χ24 = 9.5 .049
MDI technique, % correctly completed steps, median (range)
Baseline 56 (0 to 100) 64 (9 to 100)
12 mo 75 (0 to 100) 6 (−14 to 6) .45 58 (0 to 100) −16 (−1 to −31) .04 15 (7 to 22) .004
Patients with ≥1 emergency department visit, %
Baseline 10.5 9.7
12 mo 6.2 0.9 (0.7 to 1.0)c .02 12.7 1.1 (0.9 to 1.3)c .33 0.8 (0.6 to 0.99)c .03

Abbreviations: DiD, difference-in-differences; MDI, metered-dose inhaler.

a

Change within study arm relative to baseline.

b

Effect over all time points.

c

Odds ratio.