Table 2.
Phenotype of human ILCs.
| Marker | Human | |||||||
|---|---|---|---|---|---|---|---|---|
| NK | ILC1 | ILC2 | ILC3 | |||||
| CD1a | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD3 | – | (12) | – | (5, 12) | – | (12) | – | (12) |
| CD4 | – | (13) | ± | (14) | – | (13) | ± | (15) |
| CD7 | + | ND | + | (9) | + | (9) | + | (9) |
| CD11c | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD14 | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD16 | ± | (10, 15) | – | (10) | – | (10) | – | (10) |
| CD19 | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD25 | ± | (10) | + | (10) | + | (10, 14, 15) | ± | (10) |
| CD34 | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD45 | + | (5, 10) | + | (10) | + | (10) | + | (5, 10) |
| CD49a | ± | (15) | ± | (15) | ND | – | ND | – |
| CD56 | + | (10, 15) | – | (5, 10) | – | (9, 10) | ± | (9, 10) |
| CD69 | ± | (10) | ± | (10) | ND | – | + | (5) |
| CD94 | ± | (5, 10) | – | (5, 10, 12) | – | (5, 10, 12) | – | (5, 10, 12) |
| CD103 | ± | (15) | ± | (9, 15) | – | (9) | – | (9) |
| CD117 | ± | (10) | – | (10) | ± | (10) | + | (10) |
| CD123 | – | (5, 12) | – | (5, 12) | – | (5, 12) | – | (5, 12) |
| CD127 | ± | (10) | ± | (10) | + | (5, 10, 13) | + | (5, 10) |
| CD294 | – | (12) | – | (12) | + | (5, 12) | – | (12) |
| TCRαβ | – | (12) | – | (12) | – | (12) | – | (12) |
| TCRγδ | – | (12) | – | (12) | – | (12) | – | (12) |
| NKp46 | + | (10) | – | (10) | – | (10) | ± | (10) |
| NKp44 | ± | (10) | – | (10) | – | (10) | ± | (5, 10) |
| NKp30 | + | (10) | + | (10) | + | (10) | ± | (10) |
| NK1.1 | ± | (10) | + | (5, 10) | + | (10) | ± | (10) |
| NKG2D | + | (10) | ND | – | ND | – | ± | (10) |
ND, not determined.
+ positive; – negative; ± sometimes positive.