Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Plasma levels of complement components in the MS and NMOSD
| Complement components |
MS | NMOSD | References | ||
|---|---|---|---|---|---|
| RRMS | PPMS | SPMS | |||
|
Classical and lectin pathways |
C4a↑ in relapse C3↓ in stable MASP-2↑ |
C3↑ | C4↑ C3↑ MASP-2↑ |
C1s ↑ C3a ↑ C4a ↓ |
[19, 21, 24, 25, 30, 32] |
|
Terminal
pathway |
C9↓ | C9↓ | C9↓ | C5↑ SC5b-9↑ |
[19, 30, 32] |
| Inhibitors | C1INH↑ Factor H ↑ in relapse |
C1INH↑ Factor H ↑ |
C1INH↑ Factor H ↑ |
C1INH↑ Factor H ↑ |
[19, 28, 30] |
