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CSF levels of complement components in the MS and NMOSD
| Complement components |
MS | NMOSD | References | ||
|---|---|---|---|---|---|
| RRMS | PPMS | SPMS | |||
|
Classical and lectin pathways |
C1q ↑ C3 ↑ in relapse ↓ in stable C4a ↑ C4b ↑ in relapse |
C3↑ | C1q↑ C3↑ |
C3a – no difference MBL/MASP2 – no difference |
[20, 22–25, 31] |
|
Terminal pathway |
SC5b-9 ↑ | N/A | N/A | C5a ↑ in relapse SC5b-9 ↑ in relapse |
[26, 31] |
| Inhibitors | sCR2 ↑ Factor H ↓ in relapse |
Factor H↑ | sCR2↑ Factor H↑ |
N/A | [20, 23, 29] |
