. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Virus Genes. 2018 Oct 31;55(1):33–42. doi: 10.1007/s11262-018-1610-z

Table I.

Evolutionary differences within the surface proteins of sequences from HBV mono-infected versus HBV/HIV co-infected

ORF	Genotype A (n = 12) D (n = 23)	Genetic Variability^¥ (mean ± SE)	p-Value	Distribution of Escape Mutations
PreS1	A	0.12 ± 0.04	0.29	None DRM
PreS1	D	0.03 ± 0.02	0.29
PreS2	A	0.09 ± 0.04	0.54
PreS2	D	0.04 ± 0.02	0.54
S	A	0.02 ± 0.02	0.67
S	D	0.02 ± 0.02	0.67
Pol	A	0.05 ± 0.03	0.77
Pol	D	0.03 ± 0.02	0.77
HBV/HIV coinfected^ǂ A (n = 54) D (n = 14)	A	0.013 ± 0.01	0.87	G119R, T123A, C124R, T126N, Q129R, G130N, M133L/T, F134V, T140S
HBV/HIV coinfected^ǂ A (n = 54) D (n = 14)	D	0.018 ± 0.01	0.87	Y100C, R122K
HBV monoinfected^ǂ A (n = 12) D (n = 23)	A	0.019± 0.01	0.97	P120, G130R
HBV monoinfected^ǂ A (n = 12) D (n = 23)	D	0.02 ± 0.02	0.97	Y134H, 2*D144A

^ǂ

the sequences used for this comparison were 415bps covering the surface region. No mutations that confer resistance to known HBV antiviral drugs were observed: None drug resistance mutations (DRM) where observed in all sequences analysed.

^¥

Represents mean aa genetic variations observed in HBV sequences.