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. 2019 Jun 6;10:1307. doi: 10.3389/fimmu.2019.01307

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Copyright © 2019 Karkeni, Morin, Bou Tayeh, Goubard, Josselin, Castellano, Fauriat, Guittard, Olive and Nunès.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Vitamin D controls breast cancer tumor growth and CD8+ T cells infiltrating the tumor. VD supplementation was validated in both models by the quantification of the 25(OH)D levels and inflammatory cytokines (IL-6 and CCL5) in plasma and mRNA levels of inflammatory markers (Il6, Ccl5, Ccl2, Ccl11, and Cx3cl1) in adipocytes. Tumor size was measured and CD8+ T cells were quantified in the tumor.