Table 3.
Urinary markers in adult offspring gestated in LD and CPS conditions, and challenged with 4%NaCl for 4 weeks.
| Normal sodium (0.23%) | High sodium (4%) | |||
|---|---|---|---|---|
| LD | CPS | LD +4% NaCl | CPS +4% NaCl | |
| URINE 16-h | ||||
| Creatinine(mg/dl) | 7.95 ± 0.40 | 6.77 ± 0.47 | 4.45 ± 0.53 | 6.14 ± 0.50# |
| Proteins (mg/dl) | 2.58 ± 0.43 | 6.56 ± 0.87* | 1.22 ± 0.18 | 2.47 ± 0.36 |
| Na (mEq/L) | 0.45 ± 0.05 | 0.75 ± 0.09 | 4.48 ± 0.82* | 7.17 ± 0.92# |
| K (mEq/L) | 1.68 ± 0.13 | 2.08 ± 0.16 | 1.23 ± 0.20 | 2.23 ± 0.18 |
| Cl-(mEq/L) | 1.22 ± 0.09 | 1.24 ± 0.10 | 4.24 ± 0.76* | 6.70 ± 0.82# |
| PATHOLOGICAL MARKERS (ng/ml/16h) | ||||
| Alb | 403.2 ± 73.48 | 1145 ± 517 | 589.3 ± 214 | 993.1 ± 353.2 |
| AGP | 44.91 ± 5.37 | 36.34 ± 6.11 | 33.00 ± 5.79 | 42.01 ± 4.98 |
| Clusterin | 5090 ± 1022 | 1996 ± 848* | 3213 ± 287 | 1503 ± 690.9* |
| GST | 45.62 ± 8.13 | 144.10 ± 63.37# | 21.75 ± 3.75 | 48.41 ± 10.73# |
| Kim1 | 1.50 ± 0.54 | 14.02 ± 4.23*# | 1.34 ± 0.13 | 21.07 ± 7.45*# |
| OPN | 0.25 ± 0.9 | 13.00 ± 4.70*# | 0.23 ± 0.07 | 20.4 ± 7.70*# |
| Tim1 | 240.9 ± 78.43 | 79.69 ± 27.07 | 158.6 ± 36.56 | 107.2 ± 54.05 |
| VEGF | 5.69 ± 1.51 | 14.95 ± 4.00*# | 4.92 ± 0.56 | 28.34 ± 6.15*# |
| B2M | 555.7 ± 106.0 | 288.4 ± 155.5 | 483.1 ± 86.09 | 393.6 ± 143.3 |
| Cystatin | 7.60 ± 1.25 | 17.75 ± 3.70* | 9.73 ± 1.27 | 28.64 ± 6.06*# |
| EGF | 3.80 ± 0.62 | 16.34 ± 3.35* | 10.75 ± 1.37* | 26.82 ± 5.56*# |
| Lipocalin | 1.90 ± 0.31 | 13.09 ± 4.46* | 2.71 ± 0.45* | 21.28 ± 7.42* |
| Calbindin | 1758 ± 1154 | 264.8 ± 75.58 | 1245 ± 592.2 | 332.7 ± 159.9 |
| IP-10 | 0.29 ± 0.12 | 12.39 ± 4.74* | 0.83 ± 0.18 | 20.61 ± 7.62*# |
Concentrations of electrolytes, creatinine, proteins and pathological markers and were adjusted by urine volume obtained in 16-h
*
Different from LD,
#
Different from LD +4% NaCl; p < 0.05 Kruskal-Wallis rank test corrected by False Discovery Rate. (Two-stage step-up method of Benjamini, Krieger and Yekutieli).