| Mild |
Skin and subcutaneous tissues only |
Generalized erythema, urticaria, periorbital edema or angioedema |
| Moderate |
Featured suggesting respiratory, cardiovascular or gastrointestinal involvement |
Dyspnea, stridor, wheeze, nausea, vomiting, dizziness (presyncope), diaphoresis, chest or throat tightness or abdominal pain |
| Severe |
Hypoxia, hypotension or neurologic compromise |
Cyanosis or SpO2 less than 92 percent at any stage, hypotension (SBP less than 90 mm Hg in adults), confusion, collapse, LOC or incontinence |
