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. 2019 Jun 6;13:248. doi: 10.3389/fncel.2019.00248

FIGURE 4.

FIGURE 4

Combinatorial treatment of stem cells and biomaterials containing ChABC elicits remyelination and synaptic reorganization. (A,B) Representative images of axial (A) and sagittal (B) sections stained for STEM121 (a specific marker for human cytoplasmic protein; green), MBP (red), and NF200 (magenta). Many STEM121-positive/MBP-positive graft-derived myelin sheathes were observed around NF200-positive host axons. (C) Immunoelectron microscopy images show synapses formed between host and graft-derived neurons after the combinatorial treatment. Presynaptic and postsynaptic structures indicate transmission from host neurons to graft-derived neuron (left image), and from graft-derived neurons to host neurons (right image). Annotated (H) indicates host neurons, and (G) indicates graft-derived neurons. Arrowheads indicate postsynaptic density. Figure altered with permission from Nori et al. (2018). Human oligodendrogenic neural progenitor cells delivered with chondroitinase ABC facilitate functional repair of chronic spinal cord injury (2018).