Table 2.

Differentially co-expressed genes represented in the core module.

Gene Name	Description	References
CEACAM6	– A member of the immunoglobulin cell adhesion molecule superfamily. – Located on the cell surface of the mammary, respiratory and gastrointestinal epithelium and neutrophils. – Reported to be overexpressed in colorectal and pancreatic cancers.	(33–36)
CYP4B1	– An extrahepatic form of P450s. – Has a role in the bioactivation of xenobiotics – Strongly associated with bladder cancer.	(37, 38)
EIF2S2	– Has functions in encoding eukaryotic translation initiation factor -2 (subunit 2 beta) – Involved in early steps of protein synthesis.	(39)
HID1	– Associated with the medial- and trans- Golgi membranes. – Involved in the intracellular trafficking within the Golgi region.	(40)
IFFO1	– A member of the intermediate filament family. – Essential components of the cytoskeleton and nuclear envelope.	(41, 42)
MYO18A	– An unconventional member of the myosin superfamily. – Regulates epithelial cell adhesion and migration.	(43)
PDCD2	– Encodes a highly conserved nuclear protein, – Abnormal PDCD2 expression alters cell apoptosis. – Alteration of PDCD2 expression could be conducive to human cancer development and progression.	(44)
SGIP1	– One of the key regulators of clathrin-mediated endocytosis. – Functions as an endocytic protein that alters signaling by receptors in neuronal systems – Affects energy homeostasis via interaction with endophilins.	(45, 46)
SWSAP1	– Required for efficient homologous recombination repair in mammalian cells. – Has roles in the maintenance of genomic stability and tumor suppression.	(47)
A_24_P127621 A_24_P255786 A_24_P683553 A_24_P916979	– Genes with unknown functions.