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. 2019 Feb 27;12(7):1349–1360. doi: 10.1002/cssc.201900007

Figure 3.

Figure 3

Process flowsheet for the enzymatic synthesis of the product TMCL (5), describing the synthesis of the substrate TMCH (1) and the preparation of the enzyme (4). Reaction conditions: 1 a) base‐catalyzed aldol condensation (KOH, 90 °C, 20 h), 1 b) Pd‐catalyzed hydrogenation (supercritical CO2, 104–116 °C), 5) enzymatic Baeyer–Villiger oxidation (30 °C, 28 h) with 5 a) oxidation, 5 b) co‐factor regeneration, and 5 c) spontaneous hydrolysis of the co‐product. Electricity consumptions are indicated as Ei′ and Ei′′ (see Table S1 in the Supporting Information for details). Dotted arrows indicate potential recycled streams (in the sensitivity analysis only).