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. 2002 Feb;13(2):412–424. doi: 10.1091/mbc.01-09-0434

Figure 1.

Figure 1

Different phospho-forms of Sln1 regulate two separate pathways. HOG1–dependent gene expression is activated upon accumulation of dephosphorylated Sln1 (Sln1) and SKN7-dependent gene expression is activated upon accumulation of phosphorylated Sln1 (Sln1-P) and aspartyl phosphorylation of Skn7p. In response to oxidative stress, Skn7p may undergo an uncharacterized modification or conformational change to generate Skn7-oxid. As described in the body of this article, the two forms of Skn7p, Skn7-P, and Skn7-oxid appear to bind different sequence elements. These are represented at the bottom of the figure as the SSRE (sln1 star [sln*] response element) and HSE (heat shock element).