Table I.
Characteristics of Shigella isolates analyzed in this study (n=60)
| Isolate ID | Organism | Resistant pattern | Acquired resistance genes | Chromosomal mutation | Plasmid (Inc type) | Accession no. | |||
|---|---|---|---|---|---|---|---|---|---|
| gyrA | gyrB | parC | parE | ||||||
| FC1882 | S. boydii | SXT-NAL | strA, strB, aadA1, sulII, dfrA1 | D87-Y | - | - | - | IncFII | MDDI00000000 |
| FC1764 | S. boydii | AMP-SXT | strA, strB, blaTEM-1B, qnrS1, sulII, tetA, dfrA14 | - | - | - | - | IncFII, IncFIB | MDDH00000000 |
| FC1661 | S. boydii | SXT-NAL-FIX | aadA1, sulI, tetA, dfrA1, dfrA4, blaEC | S83-L | - | - | *E135-V | IncA/C2, IncFII | MDGW00000000 |
| FC2833 | S. boydii | ALL SUSCEPTIBLE | - | - | - | - | - | IncFII | MDJL00000000 |
| FC1567 | S. boydii | AMP-SXT-NAL | dfrA3, blaEC | - | - | - | - | IncFII | MIIV00000000 |
| FC2117 | S. boydii | AMP-SXT | strA, strB, blaTEM-1B, qnrS1, sulII, tetA, dfrA14 | - | - | - | - | IncFII, IncFIB | MINP00000000 |
| FC2125 | S. boydii | SXT-NAL-NX | aadA1, dfrA1, blaEC | - | - | - | - | IncFII | MINQ00000000 |
| FC2175 | S. boydii | SXT | aadA1, dfrA1 | - | - | - | - | IncFII | MINR00000000 |
| FC2710 | S. boydii | AMP-SXT-NAL (MS) | strA. strB, blaTEM-1B, qnrS1, sulII, dfrA14 | - | - | - | - | IncFII, IncFIB | MINU00000000 |
| FC1180 | S. flexneri | AMP-SXT-NAL-NX (MS) | strA, strB, aadA1, blaOXA-1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | - | MDJJ00000000 |
| FC1139 | S. flexneri | AMP-SXT | dfrA3, blaEC | - | - | - | - | - | MECX00000000 |
| FC1172 | S. flexneri | AMP-SXT-NAL-NX (MS) | strA, strB, blaOXA-1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | - | MDJI00000000 |
| FC1056 | S. dysenteriae serotype 3 | NAL-TAX | strA, strB, aadA1, sulII, tetB, dfrA1, blaEC | - | *Q776-L | *C435-G, *S694-P | - | IncFII | MECW00000000 |
| FC1708 | S. dysenteriae serotype 3 | SXT-NAL | aadA1, blaOXA-1, tetB, dfrA1 | - | *Q776-L | *C435-G, *S694-P | - | IncFII | MIIX00000000 |
| FC1737 | S. dysenteriae serotype 3 | NAL | tetB, dfrA1 | - | *Q776-L | *C435-G, *S694-P | - | IncFII | MIIY00000000 |
| FC2531 | S. dysenteriae serotype 3 | AMP-NAL-TAX | aadA1, blaOXA-1, tetB, dfrA1, blaEC | - | *Q776-L | *C435-G, *S694-P | - | IncFII | MINS00000000 |
| FC2541 | S. dysenteriae serotype 3 | AMP-NAL-TAX | aadA1, blaOXA-1, tetB, dfrA1, blaEC | - | *Q776-L | *C435-G, *S694-P | - | IncFII | MINT00000000 |
| FC2383 | S. boydii | AMP-SXT-NAL | strA, strB, aadA1, blaTEM-1B, qnrS1, sulII, dfrA1 | - | - | - | - | IncN, IncFII | MDJK00000000 |
| FC1544 | S. boydii | AMP-SXT-NAL | strA, strB, blaTEM-1B, qnrS1, sulII, dfrA14 | D87-Y | - | - | - | IncFII, IncFIB | MECT00000000 |
| FC3196 | S. boydii | AMP-SXT-NAL | strA, strB, aadA1, blaOXA-1, sulII, tetB, dfrA1 | S83-L | - | - | - | IncFII | MINV00000000 |
| FC288 | S. sonnei | AMP-SXT-NAL-NX | strA, strB, blaEC, sulII, dfrA1 | S83-L | - | S80-I | - | Col (BS512) | NGWI00000000 |
| FC1373 | S. sonnei | AMP-SXT-NAL-NX | strA, strB, blaEC, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | NGWH00000000 |
| FC1417 | S. flexneri 4 | AMP-SXT-NAL-NX-TAX-FIX | aadA1, blaOXA-1, blaCTX-M-15, qnrS1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII, Col (MP18) | NGWG00000000 |
| FC1846 | S. flexneri 6 | AMP-SXT-NAL-TAX-FIX | blaEC, aadA1, tetB, dfrA1 | D87-Y | *Q776-L | *Q506-L | - | IncFII | NGWF00000000 |
| FC2615 | S. flexneri 6 | AMP-SXT-NAL | aadA1, blaEC, sulII, tetB, dfrA1 | D87-Y | *Q776-L | *Q506-L | - | IncFII | NGWE00000000 |
| FC906 | S. flexneri 2 | AMP-SXT-NAL-NX-TAX-FIX | strA, strB, blaEC, blaOXA-1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | NGWD00000000 |
| FC1182 | S. flexneri 1 | AMP-SXT-NAL | strA, strB, aadA1, sulII, blaTEM-1B, tetA, dfrA1 | - | - | - | - | Col (BS512), IncFIB (K) | NGWC00000000 |
| FC1772 | S. sonnei | AMP-SXT-NAL-NX-TAX-FIX | blaEC, sulI, dfrA5 | S83-L | - | S80-I | - | Col 156 | NGWB00000000 |
| FC1659 | S. sonnei | SXT-NAL | strA, strB, aadA1, blaOXA-1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I, *S542-P | - | IncFII, IncI2 | NGWA00000000 |
| FC470 | S. flexneri 2 | AMP-SXT-NAL-NX-TAX-FIX | strA, strB, blaTEM-1B, blaDHA-1, qnrB4, qnrS1, mphA, sulI, sulII, tetA, dfrA17 | - | - | - | - | IncFII, IncFIB (K) | NGVZ00000000 |
| FC1247 | S. flexneri 2 | AMP-SXT-NAL-NX-TAX-FIX | strA, strB, aadA1, blaEC, blaTEM-1B, qnrS1, sulII, tetA, dfrA1 | S83-L | - | *Q506-L | - | IncFII, IncFIB (K) | NGVY00000000 |
| FC1607 | S. flexneri 4 | AMP-SXT-NAL-NX-TAX-FIX | aadA1, strA, strB, blaEC, blaCTX-M 15, qnrS1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII, IncFIB (K) | NGVX00000000 |
| FC1481 | S. flexneri 4 | AMP-SXT-NAL-NX-TAX-FIX | strA. strB, aadA1, blaTEM-1B, blaOXA-1, blaCTX-M-15, qnrS1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII, IncFIB (K) | NGVW00000000 |
| FC3278 | S. sonnei | AMP-SXT-NAL | strA, strB, blaTEM1B, sulII, dfrA5 | S83-L | - | S80-I | - | Col 156, IncB/O/K/Z | NMYB00000000 |
| FC1244 | S. sonnei | SXT-NAL | strA, strB, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | NMYA00000000 |
| FC3433 | S. flexneri 2 | AMP-SXT-NAL-TAX | aadA1, blaEC, blaOXA-1, catA1, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | NMXZ00000000 |
| FC653 | S. sonnei | AMP-SXT-NAL | blaEC, strA, strB, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | NMXY00000000 |
| FC1170 | S. flexneri 2 | AMP-SXT-NAL | blaOXA-1, catA1, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | NMXX00000000 |
| FC1824 | S. flexneri 2 | AMP-SXT-NAL | strA, strB, blaOXA-1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | NMXW00000000 |
| FC601 | S. flexneri 1 | AMP-SXT-AZM | strA, strB, aadA1, blaTEM1B, qnrS1, sulII, tetA, dfrA1 | - | - | - | - | Col 156 | NMXV00000000 |
| FC3209 | S. sonnei | SXT-NAL-NX | strA, strB, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | NMXU00000000 |
| FC666 | S. boydii | SXT-NAL | aadA1, sulII, tetB, dfrA1 | S83-L, D87-Y | - | *Q506-L | - | IncFII | NMXT00000000 |
| FC1747 | S. sonnei | SXT-NAL | strB, strA, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | NMXS00000000 |
| FC15 | S. sonnei | AMP-SXT-NAL-NX-TAX-FIX | strB, strA, blaCTX-M-15, blaEC sulII, dfrA1 | S83-L | - | S80-I | - | Col (BS512), Col 156, Incl1 | NMXR00000000 |
| FC401 | S. flexneri 1 | AMP-SXT-NAL-NX | strA, strB, aadA1, blaTEM-1B, qnrS1, sulII, dfrA1, dfrA14 | - | - | - | - | IncFII, IncFIB (K) | NMXQ00000000 |
| FC420 | S. flexneri 2 | AMP-SXT-NAL-NX | strA, strB, blaOXA-1, sulII, tetB, dfrA1, catA1 | S83-L | - | S80-I | - | IncFII | NMXP00000000 |
| FC248 | S. flexneri | AMP-SXT-NAL-NX | blaOXA-1, tetB, dfrA1, catA1 | S83-L | - | S80-I | - | IncFII | NMXO00000000 |
| FC1642 | S. boydii | SXT-NAL | aadA1, tetB, dfrA1, sulII | S83-L, D87-Y | - | *Q506-L | - | IncFII | PDYE00000000 |
| FC1655 | S. boydii | AMP-SXT-TAX-FIX | strA, strB, aadA1, blaEC, blaCTX-M-15, qnrS1, sulII, dfrA1 | - | - | - | - | IncFII | PDYD00000000 |
| FC1676 | S. boydii | AMP-SXT | strA, strB, blaTEM-1B, qnrS1, sulII, tetA, dfrA14 | - | - | - | - | IncFII, IncFIB (K) | PDYC00000000 |
| FC1706 | S. sonnei | SXT-NAL | dfrA1 | S83-L | - | S80-I | - | Incl1, Col 156 | PDYB00000000 |
| FC1628 | S. sonnei | SXT-NAL | strA, strB, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | PDYA00000000 |
| FC1667 | S. sonnei | NAL | dfrA1 | S83-L | - | S80-I | - | Col 156, ColpVC | PDXZ00000000 |
| FC1717 | S. boydii | AMP-SXT | strA, strB, blaTEM-1B, qnrS1, tetA, sulII | - | - | - | - | IncFII, IncFIB (K) | PDXY00000000 |
| FC1653 | S. sonnei | SXT-NAL | strA, strB, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156 | PDXX00000000 |
| FC1677 | S. sonnei | AMP-SXT-NAL-TAX-FIX | strA, strB, blaEC, blaCTX-M-15, sulII, dfrA1 | S83-L | - | S80-I | - | Col 156, Incl1 | PDXW00000000 |
| FC1405 | S. flexneri | AMP-SXT-TET-NAL-NX | strA, strB, aadA1, blaOXA-1, catA1, sulII, tetB, dfrA1 | S83-L | - | S80-I, *R86-C | - | IncFII | PDXV00000000 |
| FC2101 | S. flexneri 2 | AMP-SXT-NAL-TAX-FIX | aadA1, blaEC, blaCMY-4, dfrA1 | S83-L | - | S80-I | - | IncB/O/K/Z | PDXU00000000 |
| FC2414 | S. flexneri 2 | AMP-SXT-NX | strA, strB, blaOXA-1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | PDXT00000000 |
| FC1954 | S. flexneri 2 | AMP-SXT-NAL-NX | strA, strB, blaOXA-1, sulII, tetB, dfrA1 | S83-L | - | S80-I | - | IncFII | PDXS00000000 |
*Novel mutations. AMP, ampicillin; SXT, trimethoprim/sulphamethoxazole; NAL, nalidixic acid; NX, norfloxacin; TAX, cefotaxime; FIX, cefixime; AZM, azithromycin