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. 2019 Jun 6;10:1304. doi: 10.3389/fimmu.2019.01304

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Copyright © 2019 Wu, Li, Jin, Qu, Liang, Zhu, Du, Jie and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Migration assay images; (B) Kirenol inhibited the migration of FLS; (C) Kirenol inhibited the migration of FLS stimulated with TNF-α (100 ng/ml); (D) Kirenol inhibited the migration of FLS stimulated with IL-17A (100 ng/ml); (E) Invasion assay images; (F) Kirenol inhibited the invasion of FLS; (G) Kirenol inhibited the invasion of FLS stimulated with TNF-α (100 ng/ml); (H) Kirenol inhibited the invasion of FLS stimulated with IL-17A (100 ng/ml); *p < 0.05, **p < 0.01, ***p < 0.01 as assessed by the Kruskal-Wallis test and the Mann-Whitney U-test.