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. 2019 Jun 6;10:1304. doi: 10.3389/fimmu.2019.01304

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Copyright © 2019 Wu, Li, Jin, Qu, Liang, Zhu, Du, Jie and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Murine arthritis model (control(0 mg/Kg.d), 7.5 mg/Kg.d, and 30 mg/Kg.d Kirenol groups); (B) Arthritis scores for these three groups, with a significant difference between the control vs. 30 mg/Kg.d group; (C) Body weight did not differ significantly between groups. (D) a and d: Immunohistochemistry in the control group showed severe synovial hyperplasia and bone and cartilage destruction; b and e: Immunohistochemistry in the 7.5 mg/Kg.d group showed synovial hyperplasia and bone and cartilage destruction; c and f: Immunohistochemistry in the 30 mg/Kg.d group showed no serious synovial hyperplasia or bone/cartilage destruction; (E) Histological scores in the three groups, with a significant difference between the control group vs. the 30 mg/Kg.d group; (F) Synovial inflammation scores for the three groups, with a significant difference between the control group vs. the 30 mg/Kg.d group; (G) Bone erosion scores of three groups, with a significant difference between the control group vs. the 30 mg/Kg.d group; *p < 0.05, **p < 0.01, ***p < 0.01 as assessed by the Kruskal-Wallis test.