Table 2. Univariate and multivariate analysis of SERPINE1 mRNA level and survival in TCGA STAD dataset.
| Variable | Univariate analysis | Multivariate analysis3 | ||||
|---|---|---|---|---|---|---|
| HR1 | 95%CI2 | p-value | HR | 95%CI | p-value | |
| Overall survival (n = 351) | ||||||
| Gender | ||||||
| Male (n = 220) | 1.325 | 0.924–1.900 | 0.125 | |||
| Female (n = 131) | ||||||
| Age (years) | ||||||
| >60 (n = 234) | 1.731 | 1.182–2.533 | 0.005 | 2.076 | 1.407–3.062 | 0.000 |
| ≤60 (n = 117) | ||||||
| T stage | ||||||
| T3/T4 (n = 263) | 1.715 | 1.109–2.652 | 0.015 | 1.198 | 0.720–1.994 | 0.486 |
| T1/T2 (n = 88) | ||||||
| N stage | ||||||
| N1/2/3 (n = 241) | 1.906 | 1.259–2.885 | 0.002 | 1.405 | 0.797–2.478 | 0.240 |
| N0 (n = 110) | ||||||
| M stage | ||||||
| M1 (n = 24) | 1.945 | 1.074–3.523 | 0.028 | 1.993 | 1.073–3.702 | 0.029 |
| M0 (n = 327) | ||||||
| TNM stage | ||||||
| Stage III/IV (n = 193) | 1.944 | 1.359–2.779 | 0.000 | 1.325 | 0.764–2.298 | 0.316 |
| Stage I/II (n = 158) | ||||||
| G grade | ||||||
| G3 (n = 226) | 1.434 | 1.002–2.052 | 0.049 | 1.452 | 1.006–2.094 | 0.046 |
| G1/G2 (n = 125) | ||||||
| SERPINE1 | ||||||
| High (n = 176) | 1.941 | 1.377–2.737 | 0.000 | 1.843 | 1.305–2.603 | 0.001 |
| Low (n = 175) | ||||||
| Disease-free survival (n = 280) | ||||||
| Gender | ||||||
| Male (n = 178) | 2.179 | 1.357–3.497 | 0.001 | 2.021 | 1.256–3.252 | 0.004 |
| Female (n = 102) | ||||||
| Age (years) | ||||||
| >60 (n = 175) | 0.999 | 0.670–1.490 | 0.996 | |||
| ≤60 (n = 105) | ||||||
| T stage | ||||||
| T3/T4 (n = 204) | 1.408 | 0.882–2.247 | 0.151 | |||
| T1/T2 (n = 76) | ||||||
| N stage | ||||||
| N1/2/3 (n = 182) | 1.774 | 1.121–2.807 | 0.014 | 1.658 | 0.925–2.973 | 0.089 |
| N0 (n = 98) | ||||||
| M stage | ||||||
| M1 (n = 16) | 1.482 | 0.647–3.393 | 0.352 | |||
| M0 (n = 264) | ||||||
| TNM stage | ||||||
| Stage III/IV (n = 142) | 1.500 | 1.007–2.234 | 0.046 | 1.030 | 0.620–1.711 | 0.908 |
| Stage I/II (n = 138) | ||||||
| G grade | ||||||
| G3 (n = 176) | 1.198 | 0.795–1.805 | 0.388 | |||
| G1/G2 (n = 104) | ||||||
| SERPINE1 | ||||||
| High (n = 140) | 1.800 | 1.206–2.687 | 0.004 | 1.755 | 1.175–2.621 | 0.006 |
| Low (n = 140) | ||||||
Notes:
1
Hazard ratio.
2
Confidence interval of the HR.
3
Multivariate analysis of SERPINE1 was adjusted for included data like T, N, M stages, G grades, age or gender.