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. 2019 Jun 6;10:1270. doi: 10.3389/fimmu.2019.01270

Figure 1.

Figure 1

N-Formyl peptide mediated pathophysiology of SIRS and sepsis. This figure shows the pathogenic effect of NFPs on the vascular endothelium via FPR-1 activation. FPR-1 activation results in dysfunction of the vascular barrier allowing infiltration of immune cells and molecules into the interstitial and extravascular space. NFPs, bacterial and mitochondrial N-Formyl peptides; FPR-1, formyl peptide receptor-1; TNF-α, tumor necrosis factor alpha; ILF-1β, interleukin-1 beta; IFNγ, Interferon gamma; ROS, reactive oxygen species.