Table 4.

Significant connectivity changes and their T values showing the strength of connectivity in our study groups

DMN
Seed	Regions	DNP vs. healthy controls		HNP vs. healthy controls		DC vs. healthy controls
		T value	p*	T value	p*	T value	p*
MPFC	R cingulate	13.59	0.0026	3.28	0.036	insignificant
	R inferior parietal lobule	4.39	0.0235	4.48	0.0122	5.16	0.0174
	L inferior parietal lobule	7.90	0.004	4.84	0.0102	6.11	0.0115
	L medial temporal	4.19	0.026	insignificant		insignificant
R DLPFC	MPFC	-3.43	0.047	insignificant		-4.47	0.0443
L Medial temporal	L cingulate	9.61	0.0105	7.06	0.0043	11.73	0.0048
Posterior cingulate cortex/Precuneus	L inferior parietal lobule	5.50	0.0189	4.00	0.0435	insignificant
	MPFC	10.32	0.0053	3.88	0.0435	7.01	0.0185
L cingulate	L inferior parietal lobule	5.32	0.0274	3.47	0.0355	insignificant
Insula-cingulate network
Seed	Regions	DNP vs. healthy controls		HNP vs. healthy controls		DC vs. healthy controls
		T value	p*	T value	p*	T value	p*
R insula	L insula	7.78	0.0225	12.82	0.0004	7.11	0.0179
	R cingulate	5.41	0.0362	6.61	0.0031	4.61	0.047
L insula	L inferior parietal lobule	insignificant		-4.20	0.0203	insignificant
	L anterior cingulate cortex	insignificant		3.84	0.0258	insignificant
L anterior cingulate cortex	Posterior cingulate cortex/Precuneus	4.94	0.0358	insignificant		insignificant

^*All p values are corrected for multicomparisons.

DMN, default mode network; MPFC, medial prefrontal cortex; R, right; L, left; DLPFC, dorsolateral prefrontal cortex; DNP, painful diabetic neuropathy; HNP, hereditary neuropathy; DC, diabetic controls.