Table 3.
Distribution of MBL2 gene polymorphisms according to groups
| MBL2 Gene Polymorphisms n (%) | OR (95% CI) Comparison with | ||||
|---|---|---|---|---|---|
| Yes (n=63) | No (n=99) | Controls | Non-PANDAS | PANDAS | |
| Any variant | |||||
| Control Group | 15 (25.0) | 45 (75.0) | |||
| OCD Group | 48 (47.1) | 54 (52.9) | 2.66 (1.32–5.38) α | ||
| OCD Subgroups | |||||
| PANDAS | 37 (62.7) | 22 (37.3) | 5.05 (2.29–11.08)* | 5.04 (1.61–15.79) α | |
| PANDAS-Variant | 6 (26.1) | 17 (73.9) | 1.05 (0.35–3.17) | 1.05 (0.26–4.18) | 0.21 (0.07–0.61) β |
| Non-PANDAS | 5 (25.0) | 15 (75.0) | 1.00 (0.31–3.21) | ||
| MBL2 codon 54 | |||||
| Control Group | 8 (13.3) | 52 (86.7) | |||
| OCD Group | 32 (31.4) | 70 (68.6) | 2.97 (1.26–6.97) β | ||
| OCD Subgroups | |||||
| PANDAS | 23 (39.0) | 36 (61.0) | 4.15 (1.67–10.31) α | 3.62 (0.95–13.74) β | |
| PANDAS-Variant | 6 (26.1) | 17 (73.9) | 2.29 (0.69–7.55) | 2.00 (0.42–9.33) | 0.55 (0.19–1.60) |
| Non-PANDAS | 3 (15.0) | 17 (85.0) | 1.14 (0.27–4.81) | ||
Notes: Chi-square test was used for comparisons between the groups;
β
p value ≤0.05;
α
p value ≤0.005;
*
p value=0.0001; OR, odds ratio; CI, confidence interval
Any variant, presence of AB, BB, AC, CC, AD or DD genotypes; MBL2 gene, mannose binding lectin-2 gene; N-, non-PANDAS; OCD, obsessive compulsive disorder; PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections;-V, variant;