Table 4.
Results of two models of multinomial logistic regression analyses
| PANDAS | PANDAS-Variant | |||||
|---|---|---|---|---|---|---|
| B | OR (95% CI) | p value | B | OR (95% CI) | p value | |
| First Model | ||||||
| Gender | 0.857 | 2.35 (0.48–11.51) | 0.290 | -0.029 | 0.97 (0.20–4.51) | 0.970 |
| Comorbidity | -2.120 | 0.12 (0.00–3.99) | 0.236 | 15.666 | 636.8 (636.8–636.8) x3 | - |
| OCD/TD in family | 0.565 | 1.76 (0.25–12.34) | 0.570 | 0.605 | 1.83 (0.28–11.65) | 0.522 |
| Tonsillectomy | 3.334 | 28.03 (2.11–370.92) | 0.011 | 1.697 | 5.45 (0.41–71.22) | 0.196 |
| ARF/RHD in family | 3.904 | 49.62 (6.12–401.71) | 0.000 | 1.703 | 5.49 (1.06–28.38) | 0.042 |
| Any variant | 2.675 | 14.50 (2.49–84.19) | 0.003 | 0.794 | 2.21 (0.40–12.19) | 0.362 |
| Second Model | ||||||
| Gender | 0.836 | 2.30 (0.51–10.42) | 0.277 | -0.083 | 0.92 (0.19–4.25) | 0.915 |
| Comorbidity | -1.574 | 0.20 (0.00–4.6) | 0.322 | 16.626 | 940.0 (940.0–940.0) x3 | - |
| OCD/TD in family | 0.734 | 2.08 (0.33–13.03) | 0.432 | 0.506 | 1.65 (0.26–10.29) | 0.587 |
| Tonsillectomy | 2.848 | 17.25 (1.63–182.74) | 0.018 | 1.391 | 4.01 (0.34–46.59) | 0.266 |
| ARF/RHD in family | 3.289 | 26.82 (4.06–177.06) | 0.001 | 1.443 | 4.23 (0.95–18.75) | 0.050 |
| Codon 54 polymorphism | 1.457 | 4.29 (0.75–24.40) | 0.101 | 1.009 | 2.74 (0.47–15.89) | 0.260 |
The Reference category was non-PANDAS group for each model; OR, odds ratio; CI, confidence interval; x3, value presented as 103
Abbreviations: ARF/RHD, a family history of acute rheumatic fever/rheumatic heart disease; any variant, presence of AB, BB, AC, CC, AD or DD genotypes; OCD/TDs, a family history of obsessive compulsive disorder/tic disorders; PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections