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. 2019 Jun 6;10:516. doi: 10.3389/fgene.2019.00516

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Copyright © 2019 Yoon, Gaynanova and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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True pairwise correlation values σ_jk (y-axis) vs. estimated values ${\hat{σ}}_{j k}$ (x-axis) for four methods (from left to right): SPR correlation estimation on quantitative data, SPR correlation estimation on mclr_ε-transformed compositional data, SparCC estimation (Friedman and Alm, 2012), and Pearson sample correlation on clr-transformed data [as used in SPIEC-EASI (Kurtz et al., 2015)].