Table 3.

Summary of investigated metrics for the baseline and early response FMISO dynamic PET scans in normal tissues (n=72 patients).

		Target-to-blood Ratio	k3 (min−1)	Distribution volume	K1 (min−1)	vB
Sternocleidomastoid muscle	Baseline	1.01±0.08	0.0007± 0.0006	0.89± 0.10	0.08± 0.04	0.05± 0.03
	Early response	1.00±0.09	0.0008± 0.0007	0.89± 0.12	0.09± 0.04	0.06± 0.04
	p-value*	0.46	0.78	0.98	0.24	0.13
	Mean difference	−0.01±0.09	0.0000± 0.0007	0.00± 0.07	0.01± 0.05	0.01± 0.04
Adipose tissue	Baseline	0.27±0.07	0.0004± 0.0004	0.24± 0.06	0.02± 0.01	0.01± 0.01
	Early response	0.25±0.07	0.0004± 0.0005	0.23± 0.06	0.02± 0.01 0.02 0.02	0.01± 0.01 0.01± 0.01
	p-value*	0.11	0.69	0.40	0.85	0.84
	Mean difference	−0.02±0.05	0.0000± 0.0006	−0.01± 0.05	0.00± 0.02	0.00± 0.01
Submandibular gland	Baseline	1.02±0.08	0.0002± 0.0003	1.04± 0.11	0.74± 0.53	0.16± 0.10
	Early response	1.00±0.09	0.0003± 0.0004	0.98±0.10	0.76± 0.40	0.18± 0.11
	p-value*	0.03	0.19	<0.01	0.86	0.30
	Mean difference	−0.03±0.08	0.0001± 0.0005	−0.06± 0.10	0.01± 0.55	0.02± 0.13
Parotid gland	Baseline	0.90±0.11	0.0002± 0.0004	0.88± 0.15	0.50± 0.32	0.10± 0.08
	Early response	0.87±0.11	0.0003± 0.0005	0.84± 0.11	0.56± 0.32	0.12± 0.09
	p-value*	0.13	0.17	0.09	0.35	0.37
	Mean difference	−0.03± 0.09	0.0001± 0.0006	−0.04± 0.10	0.05± 0.32	0.01± 0.10

^*Unpaired 2-tailed Student t test.