TABLE 1.
Baseline Demographic, Clinical, HIV-related Factors and Inflammatory Biomarkers by Arms
| Baseline Variables | AZT Arm N = 35, Median (IQR) |
D4T Arm N = 42, Median (IQR) |
ABC Arm N = 41, Median (IQR) |
|---|---|---|---|
| Age (yr) | 3.3 (1.7–4.3) | 2.9 (1.8–3.9) | 2.3 (1.5–3.9) |
| Male sex, n (%) | 18 (51) | 19 (45) | 21 (51) |
| Weight (kg) | 10 (8–14) | 11.7 (9–14) | 11 (8–13) |
| Height (cm) | 82 (73.2–93.6) | 85.8 (76.0–95.4) | 80 (72.5–92.4) |
| BMI (kg/m2) | 15.6 (14.50–16.53) | 15.08 (14.46–17.04) | 16.04 (15.56–16.79) |
| Weight-for-age Z score | −2 (−3.4 to −1.0) | −1.8 (−3.2 to −0.7) | −2.1 (−2.6 to-0.5) |
| Height-for-age Z score | −2.4 (−3.5 to −1.1) | −2.6 (−3.3 to −1.3) | −2.4 (−3.6 to −1.4) |
| Family history of diabetes, n (%) | 3 (9) | 3 (7) | 2 (5) |
| Glucose level (mg/dL) | 62 (50–72) | 63.3 (57–68) | 59.5 (53–69) |
| Insulin (μIU/mL) | 3 (3–3.2) | 3 (3–3) | 3 (3–6.8) |
| HOMA-IR | 0.48 (0.38–0.57) | 0.49 (0.43–0.57) | 0.49 (0.41–1.07) |
| HOMA-IR ≥3.16, n(%) | 1 (3) | 2 (5) | 2 (5) |
| Total cholesterol level (mg/dL) | 116.6 (99.8–140.5) | 116 (99.4–146.0) | 128.1 (97.7–152.4) |
| High-density lipoprotein (mg/dL) | 26.3 (18.2–30.1) | 25.9 (19.1–32.4) | 24 (19.8–34.2) |
| Low-density lipoprotein (mg/dL) | 66 (42.5–85.8) | 66.9 (48.4–87.7) | 67.2 (50.7–95.5) |
| Triglycerides (mg/dL) | 111 (87.6–159.9) | 102.6 (83.6–177.2) | 114.5 (89.7–144.1) |
| Viral load (copies/mL) | 401,200 (171,650–1,079,645) | 500,975 (224,805–1,107,900)* | 315,090 (122, 250–646,190)* |
| CD4+ T cell counts (cells/mm3) | 925.5 (676–1505) | 864.7 (648–1236) | 810.5 (672–1544) |
| CD4+ T cell percent | 21 (16–25) | 19.5 (15–22) | 21 (16.5–24) |
| sTNFRl (pg/mL) | 1221 (926–1429) | 1249 (993–1480) | 1188 (995–1572) |
| STNFR2 (pg/mL) | 5739.5 (4848–7263) | 5851 (4210–7272) | 5478 (4482–8805) |
| sCD14 (ng/mL) | 1750.5 (1394–2260) | 1778.8 (1578–2298) | 2007.5 (1615–2308) |
| sCD163 (ng/mL) | 1417.5 (1154–1588) | 1345 (1118–1533) | 1340.3 (970–1680) |
| Oxidized LDL (p/L) | 140 (64–263) | 122.5 (62–239) | 80 (60–278) |
| Fibrinogen (mg/dL) | 2008.5 (1783–2305) | 1966 (1664–2149) | 1913 (1647–2260) |
Data are median value (interquartile range) or number (%) of patients.
*
P < 0.05 for between-group differences.