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. Author manuscript; available in PMC: 2020 Feb 20.
Published in final edited form as: J Am Chem Soc. 2019 Feb 11;141(7):3083–3099. doi: 10.1021/jacs.8b12247

Figure 2.

Figure 2.

Fukuyama’s proposed biosynthesis of the Illicium sesquiterpenes wherein farnesyl pyrophosphate undergoes various cyclizations and rearrangements to reach the core skeletons of the Illicium sesquiterpenes, which are then extensively oxidized to arrive at the natural products themselves.