Fasting blood glucose (a), serum insulin (b), HbA1c (c) and glucose AUC calculated from IPGTT (d) in rats at the end of the 8 week (56 day) experimental protocol. Data are expressed as mean ± SEM, n = 6/group. *p < 0.05 vs ZSF1 lean rats;†p < 0.05 vs vehicle-treated ZSF1 obese rats. White circles, vehicle-treated ZSF1 lean rats; black circles, vehicle-treated ZSF1 obese rats; light grey circles, RB394-treated ZSF1 obese rats; dark grey circles, enalapril-treated ZSF1 obese rats