Calculated values of the collagen-positive fibrotic area in the renal cortex (a) and medulla (b) and representative photomicrographs showing renal fibrosis (arrows) (c) in rats at the end of the 8 week (56 day) experimental protocol. Data are expressed as mean ± SEM, n = 6/group. *p <0.05 vs ZSF1 lean rats;†p < 0.05 vs vehicle-treated ZSF1 obese rats. White circles, vehicle-treated ZSF1 lean rats; black circles, vehicle-treated ZSF1 obese rats; light grey circles, RB394-treated ZSF1 obese rats; dark grey circles, enalapril-treated ZSF1 obese rats. Scale bar, 20 μm. ENAL, enalapril