Table 4. Pathways associated with SPTB.
| Pathway | Pathway name | p | Corrected pa | Top genes in pathwayb |
|---|---|---|---|---|
| hsa04360 | Axon guidance | 8.6E-10 | 1.6E-07 | SLIT2,PAK6,NRP1,SEMA3E,ABLIM2 |
| hsa04510 | Focal adhesion | 6.6E-07 | 6.2E-05 | PPP1CB,AKT3,PAK6,EGFR,PARVB |
| hsa04270 | Vascular smooth muscle contraction | 1.4E-06 | 8.9E-05 | PPP1CB,PLA2G4A,KCNMA1,ADRA1B,PRKG1 |
| hsa04720 | Long-term potentiation | 2.3E-05 | 1.1E-03 | PPP1CB,GRIN2B,GRM5,CAMK2G,PLCB1 |
| hsa04730 | Long-term depression | 7.0E-05 | 2.6E-03 | PLA2G4A,GRM5,PRKG1,LYN,PLCB1 |
| hsa04012 | ErbB signaling pathway | 4.1E-04 | 0.01 | AKT3,PAK6,EGFR,PLCG1,NRG2 |
| hsa04514 | Cell adhesion molecules (CAMs) | 4.4E-04 | 0.01 | HLA-DOA,NLGN1,CDH4,ITGAM,NCAM2 |
| hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 4.7E-04 | 0.01 | CACNA2D3, CACNB2,CACNA1D,ACTN1 |
aKEGG pathways with corrected and FDR adjusted p < 0.05 shown.
bTop five genes or all genes with SNPs with p < 1E-02 in GWAS shown.