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. 2019 Jun 13;14(6):e0217880. doi: 10.1371/journal.pone.0217880

Fig 6. METH-evoked dopamine release in the nucleus accumbens.

Fig 6

(A, B) In vivo microdialysis measurements of extracellular dopamine in the nucleus accumbens in freely moving mice. Perfusates were automatically collected at 10-min intervals and DA levels were measured. The plot shows the mean ± SE of DA levels in perfusates (n = 7 per group) (A). Dopamine levels were expressed as the percentage of averaged basal values (three points, -30 ~ -20 min, -20 ~ -10 min, and -10 ~ 0 min). (B) Summary of METH-evoked dopamine release. The graph shows the mean with SE of extracellular DA levels from 0 ~ 10 min to 60 ~70 min after the METH treatment. There were significant effects of genotype (F(3, 24) = 13.319, P = 0.000) by UNIANOVA. *, P < 0.05; **, P < 0.01, significant difference between the indicated groups by Tukey’s post-hoc HSD test.