Table 7. The oogenic germline starvation response in different genetic backgrounds.

Genotype	Relevant function for this study	References	Human ortholog	Starvation response	Re-feeding
WT	Control	[7, 8]	-	Shrunken gonad	Completely recovered
ced-3(n1286)	The only effector caspase	[7, 20]	Isoform 1 Caspase-2	Shrunken gonad	Completely recovered
				Not required	Not required
ced-3(n717)	The only effector caspase	[7, 20]	Isoform 1 Caspase-2	Not required	Not required
ced-3(ok2734)	The only effector caspase		Isoform 1 Caspase-2	Not required	Not required
lin-35(n745)	Causes starvation-induced germline apoptosis	[26]	Rb	Not required	Not required
daf-16(mgDf50)	Regulates dauer diapause	[28]	FoxO	Not required	Not required
skn-1(zu135)	Dietary restriction and other stresses response	[30]	Nrf	Not required	Not required
pha-4(zu225)	Dietary restriction and other stresses response	[30]	FoxA	Not required	Not required
alg-1(gk214)	miRNA pathway and proliferation	[13]	Argonaut	Not required	Not required
rsks-1(ok1255)	Increases resistance to starvation	[31]	Putative ribosomal protein S6K	Not required	Not required
ife-1(bn127)	Regulates germline progenitor number	[32]	eIF4e	Not required	Not required
gla-3(op212)	Increased germline apoptosis	[33]	-	Not required	Not required
cep-1(gk138);ced-1::gfp	Regulates DNA-damage-induced germline apoptosis	[34]	p53 transcription factor	Not required	Not required

Hermaphrodites from the different backgrounds were selected at the mid L4, starved for 5 days and observed daily under Nomarski microscopy to compare their gonad size to that under the oogenic germline starvation response using WT hermaphrodites as a control. At day 5, the hermaphrodites were refed for 3 days and observed daily under Nomarski microscopy to determine their gonad recovery, using WT hermaphrodites as a control.