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. 2013 Nov 25;2013(11):CD003227. doi: 10.1002/14651858.CD003227.pub3
Analgesia Rescue medication
Study ID Treatment PI or PR Number with 50% PR Median time to use (h) Number using
Bagan 1998 (1) dipyrone 575 mg, n = 40
(2) dexketoprofen 12.5 mg, n = 38
(3) dexketoprofen 25 mg, n = 42		 TOTPAR 6:
(1) 8.5
(2) 10.7
(3) 13.0		 (1) 14/40
(2) 18/38
(3) 25/42		 All >6 h at 6 h:
(1) 19/40
(2) 12/38
(3) 11/42
Bhounsule 1990 (1) dipyrone 500 mg, n = 20
(2) ibuprofen 400 mg, n = 20
(3) paracetamol 600 mg, n = 20
(4) aspirin 600 mg, n = 20
(5) placebo, n = 20		 TOTPAR 6:
(1) 13.0
(2) 14.2
(3) 8.1
(4) 6.7
(5) 7.4		 (1) 12/20
(2) 13/20
(3) 7/20
(4) 5/20
(5) 6/20		 Not reported Not reported
Boraks 1987 (1) dipyrone 500 mg, n = 39
(2) aspirin 650 mg, n = 41
(3) flurbiprofen 50 mg, n = 40
(4) placebo, n = 39		 At 6 h:
(1) 28/39
(2) 25/41
(3) 25/40
(4) 16/39		 Not reported at 6 h:
(1) 6/39
(2) 1/41
(3) 4/40
(4) 20/39
Gonzalez Gracia 1994 (1) dipyrone 500 mg, n = 30
(2) ketorolac 10 mg, n = 30		 TOTPAR 6:
(1) 13.8
(2) 15.1		 (1) 19/30
(2) 22/30		 Not reported at 6 h:
(1) 14/30
(2) 11/30
Ibarra 1993 (1) dipyrone 2.5 g, n = 48
(2) ketorolac 30 mg, n = 49		 PGE: v good or excellent at 6 h:
(1) 37/48
(2) 36/49		 Not reported at 6 h:
(1) 4/48
(2) 3/49
Mendl 1992 (1) dipyrone 2.5 g iv, n = 50
(2) tramadol 100 mg iv, n = 50		 VAS TOTPAR 4:
(1) 302.3
(2) 280.0		 (1) 39/50
(2) 36/50		 Not reported Not reported
Miguel Rivero 1997 (1) dipyrone 2 g, n = 35
(2) ibuprofen arginine 400 mg, n = 36
(3) placebo, n = 35		 VAS SPID 5:
(1) 196.8
(2) 187.0
(3) 119.8		 (1) 26/35
(2) 25/36
(3) 16/35		 Not reported Not reported
Olson 1999 (1) dipyrone 500 mg, n = 27
(2) ketoprofen 25 mg, n = 28
(3) ketoprofen 50 mg, n = 26
(4) placebo, n = 27		 TOTPAR 6:
(1) 9.6
(2) 9.1
(3) 9.3
(4) 2.8		 (1) 19/27
(2) 19/28
(3) 18/26
(4) 5/27		 (1) >6
(2) >6
(3) >6
(4) 1.3		 at 6 h:
(1) 14/67
(2) 20/67
(3) 25/66
(4) 31/39
Patel 1980 (1) dipyrone 2.5 g im, n = 51
(2) pethidine 100 mg im, n = 49		 TOTPAR 6:
(1) 15.1
(2) 15.5		 (1) 37/51
(2) 36/49		 Not reported Not reported
Pinto 1984 (1) dipyrone 500 mg, n = 27
(2) paracetamol 500 mg, n = 29
(3) placebo, n = 29		 TOTPAR 4:
(1) 10.7
(2) 11.4
(3) 5.6		 (1) 21/27
(2) 24/29
(3) 10/27		 Not reported at 4 h:
(1) 2/27
(2) 0/29
(3) 8/29
Rosas Perez 1986 (1) dipyrone 1 g supp, n = 20
(2) suprofen 300 mg supp, n = 20		 VAS SPID 6:
(1) 295.8
(2) 267.7		 (1) 17/20
(2) 15/20		 Not reported Not reported
Rubinstein 1986 (1) dipyrone 1000 mg, n = 30
(2) paracetamol 500 mg, n = 30
(3) placebo, n = 30		 TOTPAR 4:
(1) 11.9
(2) 10.1
(3) 4.7		 (1) 26/30
(2) 22/30
(3) 8/30		 Not reported at 4 h:
(1) 0/30
(2) 2/30
(3) 6/30
Sakata 1986 (1) dipyrone 1000 mg, n = 29
(2) paracetamol 1000 mg, n = 30
(3) placebo, n = 27		 TOTPAR 4:
(1) 8.7
(2) 8.4
(3) 2.8		 (1) 18/29
(2) 17/30
(3) 3/27		 Not reported Not reported
Santos Pereira 1986 (1) dipyrone 1000 mg, n = 28
(2) paracetamol 1000 mg, n = 28
(3) placebo, n = 29		 SPID 4:
(1) 6.2
(2) 6.4
(3) 2.1		 (1) 22/28
(2) 21/28
(3) 7/29		 Not reported at 4 h:
(1) 1/28
(2) 0/28
(3) 11/29
Stankov 1995 (1) dipyrone 2.5 g, n = 51
(2) tramadol 100 mg, n = 49		 VAS SPID 4:
(1) 247.8
(2) 228.0		 (1) 32/51
(2) 28/49		 Not reported at 4 h:
(1) 1/51
(2) 0/49