Olson 1999

Methods	Randomised, double blind, placebo control, single oral dose. Study duration 6 h Baseline PI = severe Self assessment at t = 0.15, 0.30, 1.0, 1.5 and then hourly up to 6 h.
Participants	Post‐episiotomy or 2nd degree vaginal tear N = 108 All F Mean age: 24 years
Interventions	Dipyrone 500 mg, n = 27 Ketoprofen 25 mg, n = 28 Ketoprofen 50 mg, n = 26 Placebo, n = 27
Outcomes	PI: standard 4 point scale (0‐3) PR: standard 5 point scale (0‐4) PGE: non‐standard 4 point scale Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1. Total = 4 Remedication was allowed after 1 h
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	"individual randomisation envelope for each patient entering the study "
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Study medication not identical, but nurse prepared medication as indicated to total volume of 4 ml and administered it to the patient. Administration of study medication and observation of patient carried out by two individuals to maintain the double‐blind character.