Adverse events		Withdrawals
Study ID	Treatment	Any	Serious	Adverse event	Other
Bagan 1998	(1) dipyrone 575 mg, n = 40 (2) dexketoprofen 12.5 mg, n = 38 (3) dexketoprofen 25 mg, n = 42	13 participants in total reported 18 events (1) somnolence, headache (2) somnolence, gastric discomfort, nausea, vomiting, dizziness, tiredness, other	None	None	None
Bhounsule 1990	(1) dipyrone 500 mg, n = 20 (2) ibuprofen 400 mg, n = 20 (3) paracetamol 600 mg, n = 20 (4) aspirin 600 mg, n = 20 (5) placebo, n = 20	None	None	None	Not reported
Boraks 1987	(1) dipyrone 500 mg, n = 39 (2) aspirin 650 mg, n = 41 (3) flurbiprofen 50 mg, n = 40 (4) placebo, n = 39	(1) 4/39 (somnolence, dizziness, nausea, headache) (2) 6/41 (3) 7/40 (4) 8/39 (somnolence, dizziness, nausea, warm feeling)	Not reported	None reported	Not reported
Gonzalez Garcia 1994	(1) dipyrone 500 mg, n = 30 (2) ketorolac 10 mg, n = 30	(2) 2/30 (somnolence)	None	None	None
Ibarra 1993	(1) dipyrone 2.5 g, n = 48 (2) ketorolac 30 mg, n = 49	(1) 1/48 (nausea) (2) 4/49 (nausea, tiredness, headache) (mild or moderate, related to test drugs)	None	None	None
Mendl 1992	(1) dipyrone 2.5 g iv, n = 50 (2) tramadol 100 mg iv, n = 50	"No clinically relevant side effects observed"	None	None	Not reported
Miguel Rivero 1997	(1) dipyrone 2 g, n = 35 (2) ibuprofen arginine 400 mg, n = 36 (3) placebo, n = 35	(1) 0/35 (2) 1/36 (3) 1/35 (headache ‐ judged related to test drug)	None	None	None
Olson 1999	(1) dipyrone 500 mg, n = 27 (2) ketoprofen 25 mg, n = 28 (3) ketoprofen 50 mg, n = 26 (4) placebo, n = 27	"No adverse events reported during this study"	None	None	None
Patel 1980	(1) dipyrone 2.5 g im, n = 51 (2) pethidine 100 mg im, n = 49	(1) 1/51 (hypotension) (2) 1/49 (urinary retention) (not related to test drugs)	None	None	Not reported
Pinto 1984	(1) dipyrone 500 mg, n = 27 (2) paracetamol 500 mg, n = 29 (3) placebo, n = 29	(1) 1/27 (arterial hypertension)	None	None	Not reported
Rosas Perez 1986	(1) dipyrone 1 g supp, n = 20 (2) suprofen 300 mg supp, n = 20	"No undesirable side effects attributable to the product were observed"	None	None	Not reported
Rubinstein 1986	(1) dipyrone 1000 mg, n = 30 (2) paracetamol 500 mg, n = 30 (3) placebo, n = 30	(2) 1/30 (vomiting)	None	None	None
Sakata 1986	(1) dipyrone 1000 mg, n = 29 (2) paracetamol 1000 mg, n = 30 (3) placebo, n = 27	Not reported	Not reported	Not reported	Not reported
Santos Pereira 1986	(1) dipyrone 1000 mg, n = 28 (2) paracetamol 1000 mg, n = 28 (3) placebo, n = 29	"well tolerated"	Not reported	Not reported	Not reported
Stankov 1995	(1) dipyrone 2.5 g, n = 51 (2) tramadol 100 mg, n = 49	(1) 12/51 (2) 16/4 (mostly gastrointestinal with nausea, or affecting airways in participants with bronchitis)	Not reported	None	None