Bagan 1998

Methods	Randomised, double blind, active control (dexketoprofen), single and multiple oral dose. Study duration 6 h for single dose phase and 3 days for multiple dose phase. Baseline PI = moderate or severe Self assessment at t = 0, 0.15, 0.30, 1, then hourly up to 6 h for single dose phase.
Participants	Impacted third molar extraction N = 120 M 46, F 74 Mean age 25 years
Interventions	Dipyrone 575 mg, n = 40 Dexketoprofen‐trometamol 12.5 mg, n = 38 Dexketoprofen‐trometamol 25 mg, n = 42
Outcomes	PI: standard 4 point scale (0‐3) and 100mm VAS (no pain to maximum pain) PR: standard 5 point scale (0‐4) PGE: non‐standard 4 point scale Use of rescue medication Adverse events Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1. Total = 4 Rescue medication allowed after 1 h
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Low risk	"identical capsules"