Boraks 1987

Methods	Randomised, double blind, placebo control, single oral dose. Study duration 6 h. Baseline PI = moderate or severe Self assessment at t = 0, 0.5, 1, then hourly up to 6 h.
Participants	Dental extraction N = 159 M 84, F 75 Mean age: 27 years
Interventions	Dipyrone 500 mg, n = 39 Aspirin 650 mg, n = 31 Flurbiprofen 50 mg, n = 40 Placebo, n = 39
Outcomes	PI: standard 4 point scale (0‐3) PR: 5 point scale (1‐5) standard wording, but nonstandard numbering PGE: standard 5 point scale Adverse events
Notes	Oxford Quality Score: R1, DB1, W0. Total = 2 Rescue medication allowed after 1 h
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not reported