Table 2.
Genes complementing the mutants synthetically lethal with gyp1Δ
| pag mutant | No. of isolates | Complementing gene | Protein encoded |
|---|---|---|---|
| pag1 | 1 | YIL129Ca | Unknown ORF, 2376 amino acids |
| pag2 | 2 | GOS1a | Golgi SNARE protein |
| pag3 | 4 | ERG2 | Enzyme of the ergosterol biosynthesis pathway |
| pag4 | 2 | ARL1a | ARF-like protein |
| pag5 | 2 | ERG28 | Enzyme of the ergosterol biosynthesis pathway |
| pag6 | 1 | KRE9 | Glycoprotein involved in β-1,6-glucan assembly |
| pag7 | 1 | ERG11 | Enzyme of the ergosterol biosynthesis pathway |
| pag8 | 2 | ERG24 | Enzyme of the ergosterol biosynthesis pathway |
| pag9 | 1 | WBP1 | Oligosaccharyl transferase beta subunit |
| pag10 | 4 | VPS1 | Dynamin like protein localized on Golgi |
| pag11 | 1 | PTC1 | Ser/Thr protein phosphatase, PP2C family |
ORF, open reading frame; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor.
a
These three genes were confirmed to be linked to the mutant alleles by linkage analysis.