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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Mol Cancer Ther. 2019 Apr 8;18(6):1045–1056. doi: 10.1158/1535-7163.MCT-18-0146

Figure 4: USP14 inhibitor b-AP15 suppresses NB tumor growth in vivo.

Figure 4:

A. Representative pictures of orthotopic tumors in each group. The nude mice bearing tumors were treated with b-AP15 (5 mg/kg) and DMSO respectively for two weeks. B. Tumor weights from the last day of treatment. Data was from one experiment. **P<0.01 and ***P<0.001. C. Representative light microscopy images of cleaved capspse-3 and Ki67 immunohistochemistry staining from NGP xenograft tumors treated with b-AP15 and DMSO control. Quantification of cleaved caspase-3 and Ki67 (positive cell per high-power field) demonstrates induction of apoptosis and inhibition of tumor growth in NGP xenografts treated with b-AP15. D. The nude mice bearing tumors were treated with 5 mg/kg of b-AP15 by intraperitoneal injection once daily for two days. The mice were then euthanized, and immunoblotting assay was used to detect b-AP15-induced apoptosis.