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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Clin Neurophysiol. 2019 May;36(3):186–194. doi: 10.1097/WNP.0000000000000574

Table 2:

Individual predictors of seizure occurrence and time to seizure

Presence of Seizure Time to First Seizure

Proportions
(N = 210)
OR 95%
(LCL, UCL)
p-value HR 95%
(LCL, UCL)
p-value
Clinical Features
Male vs. Female 0.42/0.26 2.01 (1.12, 3.64) 0.021 1.78 (1.10, 2.90) 0.018
Preterm vs. Term 0.23/0.39 0.48 (0.22, 0.96) 0.044 0.58 (0.31, 1.07) 0.082
EEG Indication
Suspected seizure or both indications vs. Encephalopathy 0.39/0.19 2.73 (1.28, 6.36) 0.012 2.46 (1.22, 4.95) 0.011
Encephalopathy or both indications vs. Suspected seizure alone 0.30/0.37 0.73 (0.38, 1.33) 0.301 0.72 (0.43, 1.19) 0.197
High Risk Characteristics
Hypoxic ischemic encephalopathy (HIE) vs. No HIE 0.35/0.34 1.04 (0.52, 2.02) 0.913 0.97 (0.57, 1.68) 0.934
Therapeutic Hypothermia (TH) vs. No TH 0.33/0.35 0.93 (0.41, 2.01) 0.851 0.86 (0.45, 1.64) 0.650
ECMO vs. Patients not on ECMO 0.37/0.34 1.14 (0.46, 2.72) 0.765 1.03 (0.51, 2.07) 0.926
Cardiac Arrest (CA) vs. No CA 0.39/0.35 1.10 (0.39, 2.88) 0.842 0.97 (0.44, 2.12) 0.940
CHD vs. No CHD 0.29/0.36 0.74 (0.31, 1.65) 0.470 0.74 (0.37, 1.48) 0.389
EEG Background Features
Excessive discontinuity vs. Normal 0.46/0.11 7.10 (3.34, 16.62) <0.001 5.17 (2.53, 10.57) <0.001
Depressed and undifferentiated vs. Normal 0.77/0.11 27.78 (7.09, 142.84) <0.001 11.42 (4.63, 28.14) <0.001
Burst suppression vs. Normal 0.70/0.11 19.45 (4.58, 103.85) <0.001 10.26 (3.81, 27.68) <0.001
Extremely low voltage/isoelectric vs. Normal 0.33/0.11 4.17 (0.18, 47.98) 0.263 4.99 (0.63, 39.55) 0.127
MFS vs. Absence of MFS 0.40/0.27 1.78 (0.99, 3.25) 0.054 1.58 (0.98, 2.57) 0.062
Focal vs. Absence of focal findings 0.39/0.34 1.24 (0.49, 2.97) 0.642 1.19 (0.59, 2.38) 0.632
Sleep wake cycling 0.25/0.54 0.29 (0.16, 0.53) <0.001 0.39 (0.25, 0.63) <0.001