Table 4:
Prediction model of time to 1st seizure
| Model 2A | Model 2B | Model 2C | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate | Std Err | HR | p-value | Estimate | Std Err | HR | p-value | Estimate | Std Err | HR | p-value | |
| Male vs. Female | 0.556 | (0.248) | 1.743 | 0.025 | 0.424 | (0.255) | 1.528 | 0.096 | ||||
| Preterm vs. Term | −0.483 | (0.317) | 0.617 | 0.128 | −0.572 | (0.342) | 0.565 | 0.095 | ||||
| Suspected seizure or both indications vs. Encephalopathy | 0.917 | (0.357) | 2.503 | 0.010 | 1.039 | (0.371) | 2.828 | 0.005 | ||||
| Hypothermia vs. No hypothermia | −0.756 | (0.370) | 0.469 | 0.041 | ||||||||
| CHD vs. No CHD | −0.635 | (0.379) | 0.530 | 0.093 | ||||||||
| Excessive discontinuity vs. Normal | 1.523 | (0.369) | 4.588 | <0.001 | 1.539 | (0.393) | 4.659 | <0.001 | ||||
| Depressed and undifferentiated vs. Normal | 2.633 | (0.474) | 13.912 | <0.001 | 2.761 | (0.501) | 15.813 | <0.001 | ||||
| Burst suppression vs. Normal | 2.370 | (0.507) | 10.694 | <0.001 | 2.296 | (0.576) | 9.938 | <0.001 | ||||
| Extremely low voltage/ isoelectric vs. Normal | 1.899 | (1.068) | 6.681 | 0.076 | 2.041 | (1.147) | 7.699 | 0.075 | ||||
| MFS vs. No | 0.546 | (0.279) | 1.726 | 0.050 | 0.470 | (0.275) | 1.600 | 0.087 | ||||
| Sleep wake cycling | −0.461 | (0.279) | 0.631 | 0.098 | ||||||||
| AUC at 30 Minutes | 53.2% | 73.5% | 71.6% | |||||||||
| Optimal ES threshold* | −0.341 | 0.186 | 0.755 | |||||||||
| Sensitivity | 74.72 | 82.59 | 69.63 | |||||||||
| Specificity | 32.71 | 58.28 | 65.85 | |||||||||
| AUC at 60 Minutes | 59.4% | 71.9% | 72.8% | |||||||||
| Optimal ES threshold* | 0.020 | 0.186 | 0.755 | |||||||||
| Sensitivity | 57.14 | 79.89 | 69.04 | |||||||||
| Specificity | 60.05 | 59.39 | 67.40 | |||||||||
| AUC at 3 hours | 67.4% | 71.5% | 74.8% | |||||||||
| Optimal ES threshold* | −0.341 | −0.792 | 0.755 | |||||||||
| Sensitivity | 88.67 | 84.77 | 64.25 | |||||||||
| Specificity | 38.46 | 48.26 | 70.63 | |||||||||
| AUC at 6 hours | 69.5% | 74.5% | 79.1% | |||||||||
| Optimal ES threshold* | 0.021 | −0.792 | 0.719 | |||||||||
| Sensitivity | 57.99 | 87.33 | 69.41 | |||||||||
| Specificity | 66.53 | 51.74 | 73.22 | |||||||||
| AUC at 12 hours | 68.7% | 75.1% | 80.4% | |||||||||
| Optimal ES threshold* | 0.021 | −0.792 | 0.504 | |||||||||
| Sensitivity | 64.20 | 86.72 | 70.79 | |||||||||
| Specificity | 66.49 | 52.79 | 74.88 | |||||||||
| AUC at 24 hours | 66.7% | 76.6% | 81.1% | |||||||||
| Optimal ES threshold* | 0.021 | −0.792 | 0.232 | |||||||||
| Sensitivity | 59.38 | 88.06 | 74.87 | |||||||||
| Specificity | 66.97 | 55.81 | 69.94 | |||||||||
*
Threshold based on maximum of Youden’s Index (sum of sensitivity + specificity −1), Model 2A incorporates only clinical variables, Model 2B incorporates only EEG variable and Model 2C includes both clinical and EEG variables.