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Similarities between embryonic notochord (a) and postnatal nucleus pulposus (b). Both notochord and nucleus pulposus act as signaling center, and both express SHH which is crucial for maintenance and patterning of themselves and the surrounding structure. The young and healthy disc is vascularized, and blood vessels (red lines) are restricted at the growth plate (GP) in the vertebrae. FP- floor plate, NT- Neural tube, NP- nucleus pulposus, AF- annulus fibrosus, EP- endplate.
