Table 2.
Concentrations of TFV-DP in DBS, TFV plasma and EFV plasma as well as self-reported adherence among 137 women, grouped by viral load <50, <400 and <1000 copies/mL. Results presented as n (%) unless specified.
| Viral load <50 copies/mL | Viral load ≥50 copies/mL | Viral load <400 copies/mL | Viral load ≥400 copies/mL | Viral load <1000 copies/mL | Viral load ≥1000 copies/mL | All women | |
|---|---|---|---|---|---|---|---|
| Number of women | 88 (64) | 49 (36) | 96 (70) | 41 (30) | 98 (72) | 39 (28) | 137 |
| EFV plasma (μg/mL) | |||||||
| Median (range) | 1.9 (0.00975, 19.5) | 0.00975 (0.00975, 4.8) | 1.91 (0.00975, 19.5) | 0.00975 (0.00975, 4.8) | 1.87 (0.00975, 19.5) | 0.00975 (0.00975, 4.8) | 1.52 (0.00975, 19.5) |
| Geometric mean (95% CI) | 1.8 (1.4–2.3) | 0.03 (0.02–0.06) | 1.6 (1.2–2.1) | 0.02 (0.01–0.03) | 1.5 (1.1–2.0) | 0.02 (0.01–0.03) | 0.4 (0.3–0.6) |
| LLOQ to <0.7 | 9 (10) | 39 (80) | 11 (11) | 37 (90) | 13 (13) | 35 (90) | 48 (35) |
| 0.7 to <4 | 66 (75) | 8 (16) | 71 (74) | 3 (7) | 71 (72) | 3 (8) | 74 (54) |
| ≥4 | 13 (15) | 2 (4) | 14 (15) | 1 (2) | 14 (14) | 1 (3) | 15 (11) |
| TFV plasma (ng/mL) | |||||||
| Median (range) | 44.3 (5.0, 120) | 5.0 (5.0, 90.1) | 44.2 (5.0, 120) | 5.0 (5.0, 90.1) | 44.0 (5.0, 120) | 5.0 (5.0, 90.1) | 32.90 (5.0, 120) |
| Geometric mean (95% CI) | 35 (30–42) | 8 (6–11) | 34 (29–41) | 7 (5–8) | 33 (28–39) | 7 (5–9) | 21 (17–25) |
| LLOQ to <35.5 | 31 (35) | 42 (86) | 35 (36) | 38 (93) | 37 (38) | 36 (92) | 73 (53) |
| ≥35.5 | 57 (65) | 7 (14) | 61 (64) | 3 (7) | 61 (62) | 3 (8) | 64 (47) |
| TFV-DP DBS (fmol/punch) | |||||||
| Median (range) | 961.5 (8.3, 2402) | 8.3 (8.3, 1359) | 952.50 (8.3, 2402) | 8.3 (8.3, 930) | 940.5 (8.3, 2402) | 8.3 (8.3, 930) | 701 (8.3, 2402) |
| Geometric mean (95% CI) | 815 (670–992) | 25 (14–43) | 740 (591–926) | 16 (10–25) | 700 (551–889) | 15 (9–24) | 241 (163–336) |
| LLOQ to <350 | 7 (8) | 40 (81) | 10 (10) | 37 (90) | 12 (12) | 35 (90) | 47 (35) |
| 350 to <700 | 16 (18) | 3 (6) | 17 (18) | 2 (5) | 17 (17) | 2 (5) | 19 (14) |
| 700 to <1250 | 36 (41) | 5 (10) | 39 (41) | 2 (5) | 39 (40) | 2 (5) | 41 (30) |
| 1250 to <1850 | 23 (26) | 1 (3) | 24 (25) | 0 (0) | 24 (24) | 0 (0) | 24 (18) |
| ≥1850 | 6 (7) | 0 (0) | 6 (6) | 0 (0) | 6 (6) | 0 (0) | 6 (4) |
| Self-reported adherence in past 30 days | |||||||
| Median(range) | 100 (0–100) | 92 (0–100) | 100 (0–100) | 83 (0–100) | 100 (0–100) | 83 (0–100) | 100 (0–100) |
| Score ≤80 | 3 (3) | 20 (41) | 4 (4) | 19 (46) | 5 (5) | 18 (46) | 23 (17) |
| Score >80 and ≤100 | 23 (26) | 14 (29) | 27 (28) | 10 (24) | 28 (29) | 9 (23) | 37 (27) |
| Score=100 | 62 (70) | 15 (31) | 65 (68) | 12 (29) | 65 (66) | 12 (31) | 77 (56) |