Table 3.
Analysis of apparent anticipation effect in parent-child pairs. Pairs are “comparable” when both members’ age at last observation is older than both members’ onset age. The hypothesis that the difference in age at onset within each pair (Onsetparent – Onsetchild) is greater than zero was tested within a mixed-effects model to account for multiple observations within families.
| Pair type | N of pairs | Δ onset age in yrs, mean (95% CI) | t-value | p-value |
|---|---|---|---|---|
| All pairs | 287 | 6.4 (4.6, 8.2) | 6.9 | <0.0001 |
| “Comparable” pairs | 217 | 2.3 (1.0, 3.5) | 3.7 | 0.0003 |